Articles were included when the following inclusion criteria were met 1 randomized, double blind placebo controlled trials used for quantitative synthesis or case reports used for qualitative synthesis that assessed the effect of raloxifene on one of our outcome measures; 2 included patients with schizophrenia spectrum disorder schizophrenia, schizoaffective disorder, schizophreniform disorder or psychotic disorder not otherwise specified, according to the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders DSM III, DSM III R, DSM IV, DSM IV TR, DSM 5 34, 35, or the International Classification of Diseases ICD 9 or ICD 10; 3 studies were published in a peer reviewed journal <a href=http://accutane.one>spironolactone vs accutane</a>